PSI harnesses the vitality of the private sector to address the health problems of low-income and vulnerable populations in 65 developing countries. With programs in safe water/oral rehydration, malaria, nutrition, family planning and HIV/AIDS, PSI deploys commercial marketing strategies to promote health products, services and behavior that enable low-income and vulnerable people to lead healthier lives.

PSI/Malawi began operations in 1994 with the introduction of its Chishango male condom brand. In the late 1990s, Thanzi oral rehydration salts (ORS) and Chitetezo insecticide-treated mosquito nets (ITNs) and retreatment kits were added to the platform. In 2002, PSI/Malawi launched the household water treatment product WaterGuard liquid, and in 2006 the Procter & Gamble water treatment product PUR was added. In 2008, PSI/Malawi introduced the CARE female condom brand and two contraceptive products under the SafePlan brand. In addition to these product-oriented programs, PSI/Malawi implements health and development communication programs supporting primarily HIV/AIDS prevention.