Established in November 2018 with support from the Children’s Investment Fund Foundation and the William & Flora Hewlett Foundation, the Self-Care Trailblazer Group (SCTG) was formed to support governments in institutionalizing self-care in sexual and reproductive health policy and practice. The SCTG has accomplished this by building the evidence base and advocating for the adoption of policies and practices to advance self-care. At a time when health systems are increasingly overstretched trying to meet the demands of COVID-19, the SCTG has expanded beyond its initial focus on sexual and reproductive health and rights to other health areas.